Gene therapy offers the
promise to correct inherited forms of hearing loss as well as acquired forms
such as noise-induced hearing loss, ototoxicity, and presbycusis. However,
there are several barriers that must be overcome before such potential can be
realized. This course describes the conceptual framework that governs gene
therapy today, reveals how this framework has influenced current progress, and discusses
a re-imagining of inner ear gene therapy with the goal of achieving outcomes
that are clinically relevant and realistic.
Learning
Outcomes
You will be able
to:
Describe
the theoretical premise of gene therapy
Describe
approaches to deliver genes into the inner ear
List
genes associated with hearing loss and deafness
